Computational Pharmacology

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Halothane vs hexafluoroethane network-state response on the C. elegans Cook 2019 connectome — anesthetic pushes command-interneuron firing into quiescent regime, non-immobilizer does not, across four orders of magnitude in dose.

Anesthesia Pipeline — Network-State Validation

Connectome-constrained network-state validator for C. elegans anesthesia. Predicts immobilization EC50, mutant phenotypes, and Eger non-immobilizer specificity from literature-grounded multi-target perturbation profiles applied to a 300-neuron Brian2 brain.