Research

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Canonical-AMR top-3 across 3 days: 0.17, 0.00, 0.403

Antibiotic Resistance — Mutation Trajectory Prediction

Predicting the next resistance mutation given an ordered evolution history, over ALEdb plus CARD plus deep mutational scanning data. A LightGBM + autoregressive transformer + reranker stack lifts canonical-AMR top-3 from 0.17 to 0.403 across 14 drug classes.

Halothane vs hexafluoroethane network-state response on the C. elegans Cook 2019 connectome — anesthetic pushes command-interneuron firing into quiescent regime, non-immobilizer does not, across four orders of magnitude in dose.

Anesthesia Pipeline — Network-State Validation

Network-state validator for volatile anesthesia on a substrate-agnostic LIF integrator. Predicts EC50s, mutant magnitudes, and Eger non-immobilizer specificity from literature-grounded multi-target perturbation profiles across three independent organism calibrations (worm Cook 2019, fly Winding 2023, mouse generic random graph).

ARC-AGI puzzle showing a blue input grid transforming into a green output grid, with a multi-step transformation strip — Rohit Ravi's ARC Prize 2025 entry

ARC Prize 2025

Ongoing attempt at the ARC-AGI benchmark — a pipeline-based approach to program synthesis, symmetry reasoning, and abstraction discovery.

Illustrated C. elegans worm with colored neural-network overlay — Rohit Ravi's connectomics + transcriptomics project

C. elegans Connectomics + Transcriptomics

Multi-modal analysis asking how much of local wiring in a small nervous system is determined by topology vs. gene expression.

Cross-cohort AUROC: 0.217 Day 2 versus 0.850 Day 3 on GSE122126

cfDNA Cancer Detection — A Cross-Cohort Recovery Story

Cell-free DNA methylation cancer detection over the Loyfer atlas. Cross-cohort AUROC on GSE122126 went from 0.217 (below random, model inverted) to 0.850 across four of five cancer types. The four mechanisms that closed the gap, and the literature check that showed they're not novel.

P3/time AUROC across splits: Day 1 baseline vs Day 3 leak-clean fusion

Clinical Trial Failure Prediction

Phase-3 trial outcome prediction over the AACT clinical trials database, with a leakage audit that proved the headline number is signal, not label encoding. Audited AUROC 0.8603. The audit methodology is the part worth carrying forward, not the model.

Pipeline diagram: Cellular Automata → Attention → Causal Graph → Symbolic Rules — architecture of Rohit Ravi's Hybrid Symbolic Discovery Engine

HSDE — Hybrid Symbolic Discovery Engine

Neural-symbolic reasoning prototypes: a recursive CA + attention + symbolic hybrid, and an Enhanced Symbolic Discovery Engine targeting AIME / SAT / GSM8K.

Where is the blueprint in the C. elegans connectome — a decomposition of reproducible wiring into contact geometry, developmental timing, and a small transmitter bias, with the falsified hidden-code hypotheses

Where is the 'blueprint' in the C. elegans connectome?

A worm's genome is far too small to store its ~7,000 wiring connections one by one — yet the wiring is nearly the same in every animal. So where is the information that specifies it? This is the log of a systematic hunt: a dozen candidate 'hidden codes' tested and ruled out, and the surprisingly simple thing that was left standing.

C. elegans Tier4 substrate anatomy — 3D rendering of the whole-cell electrical model

Tier4 Substrate Anatomy — a whole-cell electrical substrate, rendered from code

An interactive 3D anatomy of the C. elegans Tier4 whole-cell electrical substrate. Every channel, receptor, pump, transporter, gap junction, and ion compartment actually present in the Brian2 model is rendered 1:1 from code with an honest ON / default-OFF / ORPHANED / NOT-INTEGRATED status.

Student Researcher