Connectomics

A new dimension to access content of this website

Halothane vs hexafluoroethane network-state response on the C. elegans Cook 2019 connectome — anesthetic pushes command-interneuron firing into quiescent regime, non-immobilizer does not, across four orders of magnitude in dose.

Anesthesia Pipeline — Network-State Validation

Network-state validator for volatile anesthesia on a substrate-agnostic LIF integrator. Predicts EC50s, mutant magnitudes, and Eger non-immobilizer specificity from literature-grounded multi-target perturbation profiles across three independent organism calibrations (worm Cook 2019, fly Winding 2023, mouse generic random graph).

Illustrated C. elegans worm with colored neural-network overlay — Rohit Ravi's connectomics + transcriptomics project

C. elegans Connectomics + Transcriptomics

Multi-modal analysis asking how much of local wiring in a small nervous system is determined by topology vs. gene expression.

Where is the blueprint in the C. elegans connectome — a decomposition of reproducible wiring into contact geometry, developmental timing, and a small transmitter bias, with the falsified hidden-code hypotheses

Where is the 'blueprint' in the C. elegans connectome?

A worm's genome is far too small to store its ~7,000 wiring connections one by one — yet the wiring is nearly the same in every animal. So where is the information that specifies it? This is the log of a systematic hunt: a dozen candidate 'hidden codes' tested and ruled out, and the surprisingly simple thing that was left standing.